HepHIV 2021 was hosted through a virtual conference platform and consisted of a mixture of plenary, abstract-driven and e-poster sessions and side-meetings. The scientific content of the abstract-driven and e-poster sessions was based on submitted abstracts, reviewed and selected by a group of independent reviewers, selected based on their scientific expertise and declaration of conflicting interests. All plenaries and panels was moderated by two representatives: one from an institutional organisation (policy, academia or international institution) and one from a community/civil society organisation.